Inheritance of testicular feminization syndrome: some negative linkage findings.

نویسندگان

  • R Sanger
  • P Tippett
  • J Gavin
  • A Gooch
  • R R Race
چکیده

Testicular feminization is a rare condition: estimates of the incidence vary from 1 in 20,000 to 1 in 130,000 births. Those affected show a normal female physique and orientation: however, they have a short vagina but no uterus, and their gonads are testes which are to be found in the abdomen or in the inguinal canal. The karyotype is male, XY (Jacobs et al., 1959). Testicular feminization is clearly inherited, though the exact manner of inheritance is in doubt: it could be an X-linked recessive character or an autosomal dominant character which is expressed only in males (Grumbach and Barr, 1958). Other XY intersexual conditions with similar patterns of inheritance, such as male pseudohermaphroditism or X-linked hypospadias, are not included in this report.

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عنوان ژورنال:
  • Journal of medical genetics

دوره 6 1  شماره 

صفحات  -

تاریخ انتشار 1969